Organic anion transporter family
Witryna9 paź 2012 · Organic anion transporters of the SLC22 family in human and rodent renal proximal tubule cells. As illustrated, human and rodent orthologs of OAT1/Oat1, OAT2/Oat2, OAT3/Oat3, OAT10/Oat10, and URAT1/Urat1 have been identified. Notable species differences are OAT4 having no identified rodent ortholog and Oat5 and Oat9 … WitrynaIn the last decade, many organic anion transporters have been isolated, characterized their distribution and substrates. The recently identified organic anion transporter family OATP (organic anion transporting polypeptide)/LST (liver-specific transporter) family, transport bile acids, hormones as well as eicosanoids, various compounds …
Organic anion transporter family
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WitrynaThis gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity … WitrynaAs a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, …
WitrynaSolute carrier family. The solute carrier ( SLC) group of membrane transport proteins include over 400 members organized into 66 families. [1] [2] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee ( HGNC) and is the … WitrynaSolute carrier organic anion transporter family member 1B1. Short names. SLCO1B1. Alternative names. Liver-specific organic anion transporter 1 (LST-1 1 publication) OATP-C 1 publication. Organic anion transporter SLC21A6 1 publication. Sodium-independent organic anion-transporting polypeptide 2 (OATP-2 2 publications)
WitrynaCarolyn M. Ecelbarger, in Sex Differences in Physiology, 2016 Organic Anion and Cation Transporters. Organic anion transporters (OATs) and organic cation transporters (OCTs) are members of the superfamily of transporters, Slc (solute carriers). Most are in the families Slc21 (also known as Slc0) and Slc22, both … WitrynaThe SLC22 family contains 13 functionally characterized human plasma membrane proteins each with 12 predicted α-helical transmembrane domains. The family comprises organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). The transport …
WitrynaOrganic anion transporters (OATs) play an essential role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many drugs and their metabolites that are important in clinical medicine. Several families of multispecific organic anion and cation …
Witryna10 sty 2003 · Solute carrier organic anion transporter family member 1A5. Alternative names. Organic anion-transporting polypeptide 3 (OATP-3) Sodium-independent organic anion transporter 3; Solute carrier family 21 member 7; Gene names. Name. Slco1a5. Synonyms. Oatp1a5, Oatp3, Slc21a7, Slco1a2. Organism names. Organism. fake purple heartWitrynaView/Edit Mouse. Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene. [5] [6] This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal … fake purring cat toyWitryna10 sty 2003 · Mediates the Na +-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2) (PubMed:10873595, PubMed:19129463). Shows a pH-sensitive substrate specificity … fake purses in cancunWitryna6 gru 2024 · Core tip: As important anion transporters, organic anion transporters (OATs) and organic anion transporter polypeptides (OATPs) have similar structures and transport substrates. So far, the role of some members of OATs and OATPs in the liver has been reported, but studies on both families are still rare. In this paper, we … domain of valuing attitude and appreciationWitryna1 sty 2006 · Several families of multispecific organic anion and cation transporters, including OAT family transporters, have recently been identified by molecular cloning. The OAT family consists of six isoforms (OAT1 – 4, URAT1, and rodent Oat5) and they are all expressed in the kidney, while some are also expressed in the liver, brain, and … fake purple flowersWitryna5 lip 2004 · Mediates the transport of organic anions such as estrone 3-sulfate and thyroid hormones 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) (PubMed:14993604, PubMed:19129463). Capable of transporting pharmacological substances such as digoxin, ouabain, methotrexate and cAMP (PubMed:14993604). … domain of used an invalid spf mechanismWitryna2 sie 2010 · Organic anion transporting polypeptides (OATPs) are uptake transporters for a broad range of endogenous compounds and xenobiotics. To investigate the physiologic and pharmacologic roles of OATPs of the 1A and 1B subfamilies, we generated mice lacking all established and predicted mouse Oatp1a/1b transporters … fake purses aster crime