Naphthoflavone
WitrynaNovophane 60 kaps. ACM Novophane to suplement diety, który zawiera w swoim składzie 15 składników aktywnych, w tym aminokwasy siarkowe, cenne witaminy i … Witrynaalpha-Naphthoflavone C19H12O2 CID 11790 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...
Naphthoflavone
Did you know?
Witrynaα-Naphthoflavone. Molecular Formula C 19 H 12 O 2; Average mass 272.297 Da; Monoisotopic mass 272.083740 Da; ChemSpider ID 11297 Witryna15 wrz 2010 · General Function. Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Specific Function. Cytochromes P450 are a group of heme-thiolate monooxygenases.
Witryna15 cze 2005 · Adult male Sprague-Dawley rats were pretreated with the CYP1A inducer beta-naphthoflavone (β-NF) (80 mg/kg/day), once daily for 4 days, followed by exposure to hyperoxic environment (O 2 > 95%) or room air (normoxia) for 60 h. Pleural effusions were measured as estimates of lung injury. Activities of hepatic and pulmonary … Witrynaβ-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as …
WitrynaThe structures of CYP1A2 and CYP1B1 could be constructed using the crystallographic data of the complex between α-naphthoflavone and CYP1 enzymes (Sansen et al., … Witrynaβ-Naphthoflavone (BNF) is an exogenous ligand for aryl hydrocarbon receptor (AhR) in humans. It is an inducer of phase I detoxification enzymes (CYPs) and phase II …
Witryna20 lip 2015 · Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer. The induction of hepatic CYP1A, especially CYP1A2, was considered to detoxify AAI so as to reduce its nephrotoxicity. We previously found that baicalin had the strong ability to …
alpha-Naphthoflavone, also known as 7,8-benzoflavone and 2-phenyl-benzo(h)chromen-4-one, is a synthetic flavone derivative. It can be prepared from 2-naphthol and cinnamaldehyde. alpha-Naphthoflavone is a potent inhibitor of the enzyme aromatase, the enzyme that converts testosterone to estrogen. alpha-Naphthoflavone has been shown … in hinh cong chua animeWitryna12 lip 2013 · The reaction was stopped by the addition of 3 μM α-naphthoflavone (for CYP1A2) or 10 mM ketoconazole (for CYP3A4). CYP activity was evaluated by measuring the fluorescence of the fluorescent metabolite generated from each CYP enzyme-specific substrate. The fluorescence was measured using a microplate … mlg scremaing kid sound instantin hinh to mau cho be gaiWitrynaA progressive decline in T(4)-UGT activity occurred over time in both rat and mouse hepatocyte cultures. Treatment of cultures with various model inducers such as phenobarbital (PB), beta-naphthoflavone (NF) and clofibric acid (CLO) induced a strong increase in T(4)-UGT activity in rat hepatocyte monolayers. mlg raleigh 2021WitrynaNaphthoflavone is a synthetic derivative of naturally occurring flavonoids that serves an important role in the treatment and prevention of OS-related diseases. The current … ml grapheneWitryna1 paź 2024 · Alpha-naphthoflavone (ANF) is an effective AHR inhibitor. The present study was designed to explore the hepatoprotective effect of ANF in high fat diet (HFD)-induced NAFLD mice and oleic acid (OA)-treated HepG2 hepatocytes. Mice were fed HFD to induce NAFLD, HepG2 cells were exposed to OA to induce hepatocyte injury, … mlg security servicesWitryna14 paź 2016 · Enzyme Inhibition Kinetics. A kinetic study of formation of 4-OH-E2 from E2 catalyzed by human recombinant CYP1B1 was analyzed in the presence of α-naphthoflavone (50 nM) and β-naphthoflavone (50 nM) using Michaelis–Menten kinetics model (Fig. 2).The V max and K i values were 1.05 pmol μg protein −1 min −1 … in hinh to mau cho be trai