Webb15 mars 2008 · Streptozotocin (STZ) is an antibiotic that can cause pancreatic β-cell destruction, so it is widely used experimentally as an agent capable of inducing insulin-dependent diabetes mellitus (IDDM), also known as type 1 diabetes mellitus (T1DM). WebbOur objective was to establish a diabetes mellitus type 2 (DM2) model in rats using a high-fat diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control group (commercial feed), and HF-STZ group, (66.5%-commercial feed, 13.5%-lard, and 20%-sugar). STZ (40mg/kg i.p.) or vehicle was administered on the 13 th day.
Very-low-dose streptozotocin induces diabetes in insulin
Webb11 mars 2011 · After each period of diet exposure, rats (n = 9-13/group/food exposure time) were slightly anesthetized with sodium pentobarbital ip (40/mg/kg), weighed and killed by decapitation. Blood was collected from the ruptured cervical vessels for determination of leptin levels. WebbStreptozotocin-induced diabetic models in mice and rats. Streptozotocin (STZ) is an antibiotic that can cause pancreatic β-cell destruction, so it is widely used … dogfish tackle \u0026 marine
Recovery of Islet β-Cell Function in Streptozotocin- Induced Diabetic Mice
Webb21 juli 2024 · The effects of STZ in different doses on the observed parameters (4 neuroinflammatory markers and 4 memory parameters) showed that the responses were significantly increased at the dose of 3 mg/kg body wt. from that of 1.5 mg/kg body wt. Webbthrough the skull into the brain of mouse. STZ was dis-solved in artificial CSF (25 mg/ml) solution, made freshly. The injection site was 1 mm to right or left midpoint on the line drawn through to the anterior base of the ears. Injections were performed into right or left ventricle randomly. Two doses of STZ (3 mg/kg) were administered Webb× Close. The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. dog face on pajama bottoms