Klf2 hippo
WebNov 30, 2024 · KLF2 is a potent anti‐inflammatory transcription factor that maintains normal endothelial function. 5 To determine whether SAHA‐mediated KLF2 upregulation improves EC function, the effect of SAHA on TNFα‐induced monocyte adhesion to … WebJun 5, 2014 · Highlights. •. Klf2 is critical for ground state pluripotency. •. Klf2 is negatively regulated by Mek/Erk signaling at the posttranslational level. •. Erk2 directly interacts with and phosphorylates Klf2. •. Overexpression of Klf2 can replace Mek inhibition during ground state pluripotency.
Klf2 hippo
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WebNov 18, 2024 · KLF2 regulates metaflammation transcription in macrophages RNA-sequencing of bone marrow-derived macrophages (BMDMs) isolated from myeloid … WebNov 25, 2010 · KLF2 was initially found in T cells to maintain the quiescent state of single-positive CD4 + or CD8 + T cells. 22, 25 KLF2 also inhibits Jurkat T-cell growth by inhibiting DNA synthesis. 29 Mechanistically, both activation and inhibitory domains of KLF2 are required to suppress Jurkat T-cell proliferation.
WebKLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy Macroautophagy/autophagy is involved in myeloid cellular repair, destruction, and osteoclast differentiation; conversely, KLF2 (kruppel-like factor 2 [lung]) regulates myeloid cell activation and differentiation. WebCall Us 1 - 866 - 986 - 9598 [email protected] Sign Up. Login
WebMar 1, 2024 · KLF2, a member of the Kruppel-like factor family, has diverse roles in the immune system, and in particular plays a critical role in controlling migration of T (and B) … WebAug 1, 2024 · Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, …
To investigate the effects of shear flow on YAP activity in endothelial cell, we used a HUVEC cell line which is reliable and widely used in studying the mechanism of arteriosclerosis, because HUVEC cells are characterized by unlimited growth while maintaining endothelial cell characteristics16. HUVECs were … See more As UF downregulated the total abundance of YAP, we subsequently wanted to ascertain how YAP is inactivated under UF. A previous study revealed that YAP can be inactivated by … See more We subsequently examined autophagy levels in HUVECs by monitoring LC3 puncta with immunofluorescence. LC3 staining was relatively weaker in CD31-positive ECs treated with DF compared with those exposed to … See more Post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, define the transcriptional activation of YAP. In … See more To ascertain whether autophagy inhibits the development of atherosclerosis by manipulating YAP, we treated HUVECs with a … See more
WebMar 27, 2024 · KLF2-V5– or mock-transduced HUVECs were washed twice with PBS before cross-linking with 37% formaldehyde for 10 min at room temperature. Cells were lysed with cytoplasmic lysis buffer, followed by nuclear lysis buffer. Extracts of nuclei were sonified using Bransons Diagenode for 45 cycles on high amplitude (30 s on followed by 30 s off) … optical bendingWebApr 25, 2006 · The mechanisms regulating activation of monocytes remain incompletely understood. Herein we provide evidence that Kruppel-like factor 2 (KLF2) inhibits proinflammatory activation of monocytes. In vitro, KLF2 expression in monocytes is reduced by cytokine activation or differentiation. Consistent with this observation, KLF2 expression … optical bench convex lensWebNrf2 is elevated by KLF2 and prolonged laminar shear stress, and it up-regulates transcription of NAD(P)H dehydrogenase quinone (NQO1) and heme oxygenase (HO-1). … optical benefit for employeesWebSep 16, 2024 · Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, … optical bench railWebI made this just to speed a few things up. Ive updated a few descriptions in the file and added 2 new features. I am currently working on a more featured chat menu, planning to … optical benefit irelandWebJul 31, 2009 · KLF2 expression was induced acutely by hypoxia in endothelial cells. Adenoviral overexpression of KLF2 inhibited hypoxia-induced expression of HIF-1alpha and its target genes such as interleukin 8, angiopoietin-2, and vascular endothelial growth factor in endothelial cells. optical bench lab lensWebHippo信号通路由一组保守的激酶构成，是一条抑制细胞生长的信号通路。 在哺乳动物中，Hippo信号通路上游的膜蛋白受体感受到胞外环境的生长抑制信号后，经过一系列激酶的磷酸化反应，最终作用于下游效应因子YAP … optical bellingham wa