High-affinity choline transporter 1
Web21 de set. de 2024 · The high-affinity choline transporter CHT1, which is the rate-limiting step for acetylcholine (ACh) synthesis, exerts a crucial role in the functioning of the cholinergic system. 8 CHT1 is present on the presynaptic terminal of cholinergic neurons and can take up choline hydrolyzed from ACh at the synaptic cleft into the presynaptic … WebThe transporter protein was cloned and identified by Okuda and co-workers in 2000, and shown to exhibit high-affinity, sodium-dependent choline uptake ( Km ~2 μM) which …
High-affinity choline transporter 1
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Web18 de jan. de 2010 · The cho-1 gene in Caenorhabditis elegans encodes a high-affinity plasma-membrane choline transporter believed to be rate limiting for acetylcholine (ACh) synthesis in cholinergic nerve terminals. Web22 de jul. de 2024 · The first transporter is high-affinity choline transporter 1 (CHT1) that is expressed in cholinergic neurons and is linked to acetylcholine synthesis, which has a …
WebThe molecular entity for the high-affinity choline transporter was identified and is designated CHT1, which mediates Na+- and Cl−-dependent choline uptake with high sensitivity to hemicholinium-3 and has been characterized both at the molecular and functional levels. The cholinergic neurons have long been a model for biochemical … Web1 de jan. de 2005 · Kus, L. et al. Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system. J. Comp. Neurol. 463, 341–357 (2003).
Web3 de nov. de 2000 · The presence of the high-affinity choline transporter Choline transporter 1 in nerve fibers and epithelial cells in the human and rat skin supporting the … WebComponents. integral component of membrane / neuronal cell body / plasma membrane. General Function. Choline:sodium symporter activity. Specific Function. Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent.
WebLOC799259 high-affinity choline transporter 1-like [ (zebrafish)] Gene ID: 799259, updated on 4-Nov-2024.
WebCHT1 is a member of the SLC5 family of solute transporters and is assigned to SLC5A7 ( 12. ). Its amino acid sequence has 20–25% homology with that of other members of this family ( 13. ). It has been assumed that all members of the family possess a common 13-transmembrane domain core ( 14. how many siblings did marcus garvey haveWeb1 de mai. de 1990 · It is demonstrated that these two affinity states of [3H]HC‐3 binding are totally interconvertible; addition of 0.1 mM ATP in the binding assay medium quantitatively converted all the binding sites to the low‐affinity state, whereas addition of 1 mM β,γ‐methylene 5′‐ATP quantitatively Conversion of all thebinding sites toThe … how did manifest endWeb10 de jun. de 2005 · Maintenance of acetylcholine synthesis depends on the effective functioning of a high-affinity sodium-dependent choline transporter (CHT1). Recent studies have shown that this transporter is predominantly localized inside the cell, unlike other neurotransmitter transporters, suggesting that the trafficking of CHT1 to and from … how many siblings did marilyn monroe haveWebThe molecular entity for the high-affinity choline transporter was identified and is designated CHT1, which mediates Na+- and Cl−-dependent choline uptake with high … how did manolos mom die the book of lifeWebCHT1 protein is mainly found in intracellular organelles, such as endosomal compartments and synaptic vesicles. The presence of CHT1 at the plasma membrane is limited by … how did manny khoshbin get richWebA choline uptake system with a high affinity for choline has long been assumed to be present in cholinergic neurons. Very recently, the molecular entity for the high-affinity … how many siblings did marian anderson haveWeb1 de out. de 2002 · High-affinity choline transporter 1. Gene. ChT. Status. UniProtKB reviewed (Swiss-Prot) Organism. Drosophila melanogaster ... Function. function. Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity). By ... how many siblings did marco polo have