Fnip2

WebJun 24, 2024 · LncRNA-FNIP2/miR-24-3p/FNIP2axis was considered as a potential candidate that may participate in lipid synthesis. Experimentally, the objective reality of lncRNA-FNIP2/miR-24-3p/FNIP2axis was clarified and the regulation effect of lncRNA-FNIP2/miR-24-3p/FNIP2axis on synthesis was validated. WebComponent of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD …

Folliculin-interacting protein FNIP2 impacts on overweight and …

WebThe deduced 1,114-amino acid protein shares 49% identity with FNIP1. Quantitative real-time PCR detected variable FNIP2 expression in most tissues examined, with highest … WebFNIP2 Antibody Summary Applications/Dilutions Packaging, Storage & Formulations Alternate Names for FNIP2 Antibody FNIP1-like protein FNIPL folliculin interacting protein 2 Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. philippines to australia flight price https://jbtravelers.com

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WebNov 22, 2024 · To determine the lysosomal function of FLCN, we reconstituted the human lysosomal FLCN complex (LFC) containing FLCN, its partner FLCN-interacting protein 2 (FNIP2), and the RagA GDP:RagC GTP GTPases as they exist in the starved state with their lysosomal anchor Ragulator complex and determined its cryo-electron microscopy … WebJun 24, 2024 · It was showed that the co-transfection between wild type FNIP2 3′UTR and miR-24-3p could reduce the luciferase activity , indicating a target relationship between FNIP2 and miR-24-3p. qRT-PCR and the Western Blot results showed that miR-24-3p does have a posttranscriptional regulation on FNIP2, which miR-24-3p downregulated FNIP2 … WebOct 31, 2024 · FNIP2 gene expression significantly correlated with both FNIP1 and FLCN (Additional file 1: Fig. S3B) and we observed associations between the levels of FLCN expression and increased weight, BMI, fat mass, visceral fatness, waist and hip circumferences, DBP, and blood levels of glucose, leptin, and triglycerides; and … philippines tiny monkey

Folliculin-interacting proteins Fnip1 and Fnip2 play critical …

Category:FNIP2 folliculin interacting protein 2 - NIH Genetic Testing …

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Fnip2

Loss of FLCN-FNIP1/2 induces a non-canonical interferon

WebAnti-FNIP2 antibody Description Rabbit polyclonal to FNIP2 Host species Rabbit Specificity ab106611 is predicted to not cross-react with FNIP1. Tested applications Suitable for: WB more details Species reactivity Reacts with: Rat Immunogen Synthetic peptide corresponding to 16 amino acids near the C terminal end of Human FNIP2 (NP_065891). WebView FNIP2 mouse/human homology from Alliance Direct with: genes, location, sequences, associated human diseases

Fnip2

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WebThe putative FNIP2 LIR motif mapped to a >300-residue disordered loop within FLCN/FNIP2 from the LFC complex that was recently solved by cryo–electron microscopy (cryo-EM) … WebFunction. This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa …

WebGermline mutations in the Folliculin (FLCN) tumor suppressor gene cause Birt-Hogg-Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing carriers to kidney … WebNov 27, 2024 · FLCN-FNIP2 adopts an extended conformation with two pairs of heterodimerized domains. The Longin domains heterodimerize and contact both nucleotide binding domains of the Rag heterodimer, while the DENN domains interact at the distal end of the structure.

WebFnip2 Name folliculin interacting protein 2 Synonyms D630023B12Rik, mKIAA1450 Feature Type protein coding gene IDs MGI:2683054 NCBI Gene: 329679 Alliance gene page … WebFNIP2 (Folliculin Interacting Protein 2) is a Protein Coding gene. Diseases associated with FNIP2 include Birt-Hogg-Dube Syndrome and Familial Renal Oncocytoma . Among its …

WebJan 18, 2024 · Surprisingly, the absence of FLCN or its binding partners FNIP1/FNIP2 induces interferon response genes independently of interferon. Mechanistically, FLCN loss promotes STAT2 recruitment to chromatin and slows cellular proliferation. Our integrated analysis identifies STAT1/2 signaling as a novel target of FLCN in renal cells and BHD …

WebMar 3, 2024 · FLCN forms complexes with two large interacting proteins, FNIP1 and FNIP2. Structural studies have shown that both FLCN and FNIPs contain longin and differentially expressed in normal versus neoplastic cells (DENN) domains, typically involved in the regulation of small GTPases. philippines to australia dhlWebFLCN-FNIP2 adopts an extended conformation with two pairs of heterodimerized domains. The Longin domains heterodimerize and contact both nucleotide binding domains of the … trupan light weight mdfWebAnti-FNIP2 Rabbit Polyclonal Antibody Supplier: Abnova Rabbit polyclonal antibody raised against synthetic peptide of FNIP2. Recommended Dilutions: Western Blot: 1-2 ?g/ml Type: Primary Antigen: FNIP2 Clonality: Unconjugated Clone: Polyclonal Conjugation: Epitope: Host: Isotype: Rabbit Reactivity: Human, Mouse, Rat Order Now SPECIFICATIONS … trupanion vs healthy paws pet insuranceWebin kidney, the Fnip2 expression level, which is commensurate with that of Fnip1, might maintain Fnip function in Fnip1-deficient kidneys, and therefore, double inactivation … trupanion pricing philosophyWebZfish genes fnip2 Annotations are indicated with nodes colored by organism: Human , Mouse , Rat , Zfish Relations between GO terms are indicated by colored edges "is_a" ; "part_of" ; "regulates"; "positively_regulates" ; trupath homesWebJun 24, 2024 · 中国科学院上海巴斯德研究所的定位与目标是揭示重大传染病病原体持续感染致病机制、免疫保护机制与免疫病理机制，突破免疫治疗的共性技术瓶颈问题，形成重大传染病的诊断、预防、治疗解决方案。依托巴斯德国际网络联盟，服务国家、区域、全球传染病防控需求，建成传染病防控领域中特色 ... trupath staffingWebFNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss … philippines to bali airfare